LINE-1 methylation is inherited in familial testicular cancer kindreds

LINE-1 methylation is inherited in familial testicular cancer kindreds

Blog Article

Abstract Background Testicular germ cell tumors (TGCT) are the most frequent cancers among young men.There is a clear familial component to TGCT etiology, but no high-penetrance susceptibility gene has been identified.Epigenetic aberrations of the genome represent an alternative mechanism for cancer susceptibility; and, studies suggest that epigenetic changes that influence cancer risk can be inherited through the germline.Global DNA hypomethylation has been associated with the risk of cancers of the bladder and head/neck.Methods We performed a pilot study of global methylation at long interspersed nuclear elements-1 (LINE-1) in peripheral blood DNA isolated from 466 family members BiPAP Machine of 101 multiple-case testicular cancer families.

Results Investigating the correlation of LINE-1 methylation levels among parent-child pairs independent of affection status (n = 355) revealed a strong positive association only between mother-daughter (r = 0.48, P = r = 0.31, P = 0.02), suggesting gender-specific inheritance of methylation.Incorporating cancer status, we observed a strong correlation in LINE-1 methylation levels only among affected father-affected son pairs (r = 0.

49, P = 0.03).There was a marginally significant inverse association between lower LINE-1 methylation levels and increased TGCT risk, compared with healthy male relatives (P = 0.049).Conclusions Our data suggest that heritability of LINE-1 methylation may be gender-specific.

Further, the strong correlation between LINE-1 methylation levels among affected father-affected son pairs suggests Course a pied - Accessoires - Nutrition that transgenerational inheritance of an epigenetic event may be associated with disease risk.Larger studies are needed to clarify these preliminary observations.